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About Orafate™
 
 

Healthcare Professionals


Orafate™ is a specialized formulation of sucralfate presented in paste form. In Orafate™, 
generic sucralfate compound is reversibly cross-linked into sucralfate sheets known as 
high potency sucralfate. Sucralfate sheets assume an egg-crate configuration, a novel 
configuration that allow for efficient layering of sheets in a stackable open “egg-crate” 
fashion. 

Sucralfate sheets of Orafate™ have unique surface effects resulting in several beneficial 
outcomes for the patient with oral surgical wounds.

Orafate™ Benefits
First, in its highly layered fashion, Orafate™ binds to thrombin to assist in stopping 
venous and capillary bleeding. Second, Orafate™ covers the surgical wound with a 
protective coat that allows acceleration of healing by 366%[1] above normal. Third, 
the electro-negative micro-environ created by “sucralfate sheets” of Orafate™ facilitate 
a reversal of ion fluxes across membranes of pain receptors. The multifold coat of high 
potency sucralfate in Orafate™ facilitates reversal of proinflammatory cytokines that 
triggered release of nerve pain factors reducing them. Orafate™ is designed for the 
efficient management of oral post-surgical wounds which remains an inadequately addressed 
medical need in dentistry and otolaryngology (ENT surgery).

1. Ahmad MM, Khan AKA, McCullough. Accelerated healing using high potency sucralfate. 
A seven day randomized comparison to omeprazole, ranitidine and antacids in erosive GERD. 
2005, data reports MMI).

MECHANISM of ACTION 
Orafate™ has a mechanical action of coating. Cross-linked sheets of sucralfate layer along 
the mucosa engaging the lining. The egg-crate configuration of sucralfate sheets layer in 
stacks unavoidably engaging locally secreted growth factors. This loose engagement 
facilitate movement of growth factors to their receptors that are activated as a result. 
These events accelerate healing. The electronegative micro-environ created by “sucralfate 
sheets” quiet or neutralize ion-fluxes across membranes of mucosal nociceptors thereby 
relieving pain. Similar effects occur on mucosal receptors associated with nausea colicky 
cramp and secretory diarrhea with subsequent relief of these symptoms.

How Supplied 
Orafate™ is supplied in 1.014 fl oz (30mL) squeeze tubes (NDC 33801-030-01).

ORAFATE NDC 33801-030-01
	

Direction of Use
Following Tooth Extraction: Orafate™ should be used 3 times daily for the 1st daily then 
twice daily for 1 week or as directed by the dentist.
Following Tonsillectomy or Uvuloplasty: Squeeze out ½ to 1 tsp (2.5 – 5ml) of paste from 
bottle on to tongue, swish, gargle and/ or swallow the dose as instructed by surgeon.

FOR POST-SURGICAL ORAL WOUNDS
Following Tooth Extraction: Orafate™ should be used 3 times daily for the 1st daily then 
twice daily for 1 week or as directed by the dentist.
Following Tonsillectomy or Uvuloplasty: Squeeze out ½ to 1 tsp (2.5 – 5ml) of paste from 
bottle on to tongue, swish, gargle and/ or swallow the dose as instructed by surgeon.

FOR PERIODONTAL and GINGIVAL WOUNDS
Following Scaling and Root Planing: Orafate™ should be used 2 times daily for the 1st 
day or as directed by the dentist. Thereafter apply for four weeks.

Orafate™ as follows: ¼ teaspoon of paste may be either 
(a) brushed alone or with toothpaste over affected tooth-gum line area; 
(b) mixed with equal portions of dentifrice (tooth paste, powder, gel) and layer over 
	areas of teeth cleaned by the dentist; 
(c) dabbed directly on to affected gum margin; (d) layered onto affected gum area; or 
(e) placed in mouth, sucked back and forth through spaces between teeth.

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